杜亚伟，博士，助理研究员。2021年1月毕业于东南大学，获工学博士学位。2021至2023年在上海交通大学医学院/上海市伤骨科研究所从事博士后研究。研究领域主要聚焦于药物递送系统，特别是天然药物微纳体系调控炎症微环境。目前，已在国际著名学术期刊上发表论文四十余篇。其中，以第一作者（含共一）在Research、Adv Funct Mater、Bioact Mater等SCI期刊发表论文18篇。申请专利18项，其中授权9项。主持国家自然科学基金青年项目、中国博士后基金面上项目、上海市卫健委临床研究专项面上项目等科研项目，并入选上海市浦江人才计划和上海交通大学医学院“博士后激励计划”等人才计划。兼任中国民族医药学会方药量效研究分会常务理事，并担任多个国际著名学术期刊的客座编辑及审稿人。

研究方向

针对骨性关节炎、骨质疏松以及类风湿关节炎等骨科相关疾病的发病机制，围绕天然药物及其衍生物构建微纳递送体系，探索以生物材料学为基础的疾病治疗策略。

代表性科研论文（^#共同一作）

1. C Li^#, Y Du^#, T Zhang, H Wang, Z Hou, Y Zhang, W Cui*, W Chen*. “Genetic scissors” CRISPR/Cas9 genome editing cutting-edge biotechnology for bone and cartilage repair. Bioactive Materials. 2023. 22: 254-273

2. F Zhang^#, Y Du^#, J Zheng, Z Cai, T Ding, P Zhuang, D Yang, F Liao, Y Zhang, W Yang, Y Xiao, W He*, W Cui*, W Guo*. Oral administration of multistage albumin nanomedicine depots (MANDs) for targeted efficient alleviation of chronic inflammatory diseases. Advanced Functional Materials. 2023. 33(9): 2211644.

3. J Li^#, R Zhang^#, Y Du^#, G Liu, Q Zhai, Y Dong, W Cui*, P Jia*, Y Xu*. Osteophilic and dual-regulated alendronate-gene lipoplexes for reversing bone loss. Small. 2023.

4. Y Du^#, C Li^#, Y Zhang, W Xiong, F Wang, J Wang, Y Zhang, L Deng, X Li*, W Chen*, W Cui*. In situ-activated phospholipid-mimic artemisinin prodrug via injectable hydrogel nano/microsphere for rheumatoid arthritis therapy. Research. 2022. 2022: 0003.

5. Y Du, C Giannangelo, W He, G Shami, W Zhou, T Yang, D Creek, C Dogovski, X Li*, L Tilley*. Dimeric artesunate phosphorylcholine conjugate nano-assemblies as slow-release antimalarials to overcome Kelch 13-mutant artemisinin resistance. Antimicrobial Agents and Chemotherapy. 2022. 66(5): e02065-21.

6. C Li^#, Y Du^#, H Lv, T Zhang, J Zhang, P Zhuang, W Yang, Y Zhang, J Wang*, W Cui*, W Chen*. Injectable amphipathic artesunate prodrug-hydrogel microsphere as gene/drug nano-microplex for rheumatoid arthritis therapy. Advanced Functional Materials. 2022. 32 (44): 2206261.

7. Y Sun^#, Q Zhou^#, Y Du^#, J Sun, W Bi, W Liu, R Li, X Wu, F Yang, N Li, L Song, W Cui*, Y Yu*. Immune reprogramming engineered injectable microspheres with dual-signals for remodeling osteogenic microenvironment. Small. 2022. 18(36): 2270190.

8. W He^#, Y Du^#, Z Tao, T Wang, J Wang, C Dogovski, C Li, R Hu, C Yao*, X Li*. Dimeric artesunate-choline conjugate micelles coated with hyaluronic acid as a stable, safe and potent alternative anti-malarial injection of artesunate. International Journal of Pharmaceutics. 2021. 609: 121138.

9. Y Du^#, Z Wang^#,*, T Wang, W He, W Zhou, M Li, C Yao, X Li*. Improved anti-tumor activity of novel redox-responsive paclitaxel-encapsulated liposomes based on disulfide phosphatidylcholine. Molecular Pharmaceutics. 2020, 17(1): 262-273.

10. Y Du^#, W He^#, Q Xia, W Zhou, C Yao, X Li*. Thioether phosphatidylcholine liposomes: a novel ROS-responsive platform for drug delivery. ACS Applied Materials & Interfaces. 2019. 11(41): 37411-37420.