王非,博士,副研究员。2015年6月博士毕业于华东师范大学,同年进入上海交通大学医学院附属瑞金医院/上海市伤骨科研究所工作,2016年聘为助理研究员,2021年晋升为副研究员。主要聚焦纳米药物载体与医用材料的设计与开发,从事骨关节炎、骨质疏松和肌腱病等运动系统的防治研究围绕研究方向以通讯和第一/共一作者在国际著名学术期刊Advanced materials, Advanced Functional Materials, Biomaterials, Small, NPG Asia Materials, Acta Biomaterialia等发表相关研究论文10余篇。获得上海市卫生健康青年人才计划,主持包括国家自然科学基金、上海市科委自然基金等在内的多项科研课题。在中国生物材料学会-康复健康器械与生物材料分会和中国康复医学会-修复重建外科专业委员会兼任委员,国际华人骨研学会(ICMRS)会员等。
研究方向
1.骨疾病微环境响应的基因治疗
2.骨疾病的基因载体的设计与开发
3.骨和软骨再生智能递药系统
科研论文
1. C. Cai#, X. Zhang#, Y. Li#, X. Liu#, S. Wang, M. Lu, X. Yan, L. Deng, S. Liu*, F. Wang*, C. Fan*, Self-healing Hydrogel Embodied with Macrophage-regulation and Responsive-gene-silencing Properties for Synergistic Prevention of Peritendinous Adhesion. Advanced Materials. 2022, 34(5):2106564. Co-corresponding author
2. K. Chen#, F. Wang#, R. Ding#, Z. Cai, T. Zou, A. Zhang, D. Guo, B. Ye,* W. Cui,* M. Xiang*, Adhesive and Injectable Hydrogel Microspheres for Inner Ear Treatment. Small. 2022, 2106591.
3. B. Li#, F. Wang#, F. Hu , T. Ding, P. Huang, X. Xu, J. Liang, C. Li, Q. Zhou, M. Lu, L. Deng, L. Guo*, W. Cui*, Injectable “nano-micron” combined gene-hydrogel microspheres for local treatment of osteoarthritis. NPG Asia Materials. 2022, 14:1.
4. C. Cai#, W. Wang#, J. Liang, Y. Li, M. Lu, W. Cui, C. Fan, L. Deng, Y. Li*, F. Wang*, S. Liu*. MMP-2 Responsive Unidirectional Hydrogel-Electrospun Patch Loading TGF-β1 siRNA Polyplexes for Peritendinous Anti-Adhesion. Advanced Functional Materials. 2021, 31(6):2008364. Co-corresponding author
5. L. Zhao#, F. Wang#, Z. Cai#, Q. Zhou, B. Chen, C. Zhang, H. Liu, L. Hong, T. Zhang, J. Zhong*, W.Cui*, Z. Wang*. Improving drug utilization platform with injectable mucoadhesive hydrogel for treating ulcerative colitis. Chemical Engineering Journal. 2021. 424:130464.
6. S. Wang#, F. Wang#, Q. Zhang*, Y. Cheng*. A core–shell structured polyplex for efficient and non-toxic gene delivery, Journal of Materials Chemistry B, 2017, 5(26):5101-5108. Co-first author
7. F. Wang, L. Deng, J. Hu, Y. Cheng*, Being Two Is Better than Being One: A Facile Strategy to Fabricate Multicomponent Nanoparticles for Efficient Gene Delivery, Bioconjugate Chemistry, 2016, 27(3):638-646.
8. F. Wang, K. Hu, Y. Cheng*, Structure-activity relationship of dendrimers engineered with twenty common amino acids in gene delivery, Acta Biomaterialia, 2015, 29(1):94-102.
9. F. Wang, Y. Wang, H. Wang, N. Shao, Y. Chen, Y. Cheng*, Synergistic effect of amino acids modified on dendrimer surface in gene delivery, Biomaterials, 2014, 35(33):9187-9198. Highlighted by Faculty of 1000
10. F. Wang, N. Shao, Y. Cheng, Paramagnetic NMR investigation of dendrimer-based host-guest interactions. PLoS One. 2013, 8(6):e64722.
11. F. Wang, X. Cai, Y. Su, J. Hu, Q. Wu, H. Zhang*, J. Xiao*, Y. Cheng*, Reducing cytotoxicity while improving anti-cancer drug loading capacity of polypropylenimine dendrimers by surface acetylation, Acta Biomaterialia, 2012, 8(12):4304-4313.