阮慧瞳，博士，副研究员/硕导。本科毕业于四川大学华西药学院，2019年于复旦大学药学院毕业，获药剂学博士学位，师从陆伟跃教授、顾臻教授。2019至2021年在上海交通大学医学院/伤骨科研究所从事博士后研究。长期致力于骨、神经等相关的智能化药物递送系统策略开发，并主要在响应型微-纳材料、功能化微球设计、内源性修复策略等方面进行研究。已在国际著名学术期刊Nat. Biomed. Eng., Adv. Mater., Matter, J Control Release.等发表论文30余篇。主持国家自然科学基金青年项目，博士后科学基金面上资助，瑞金医院青年培育计划等多项基金，入选2020年国家“博新计划”、上海市“晨光计划”、上海市“超级博士后”等人才项目，担任J. Nanobiotechnol., Nano Research等国际著名学术期刊审稿人，担任Cell Press旗下综合性英文期刊The Innovation青年编委。
研究方向：
1.生理响应型纳米材料及免疫治疗策略开发；
2.多功能水凝胶微球在组织再生医学中的应用；
3.疾病微环境重构及靶向递送系统开发。
科研论文：
1. Huitong Ruan#, Quanyin Hu#, Di Wen, Qian Chen, Guojun Chen, Yifei Lu, Jinqiang Wang, Hao Cheng, Weiyue Lu*, Zhen Gu*, A Dual-Bioresponsive Drug-Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade. Advanced Materials 2019, 31(17), e1806957.
2. Huitong Ruan#, Yongfang Li#, Cheng Wang, Yixu Jiang, Yulong Han, Yiwei Li, Dandan Zheng, Jing Ye, Gang Chen, Guo-yuan Yang, Lianfu Deng, Ming Guo, Xingcai Zhang*, Yaohui Tang*, Wenguo Cui*. Click Chemistry Extracellular Vesicle/Peptide/Chemokine Nanomissiles for Treating CNS Injuries. Acta Pharmaceutica Sinica B 2022, https://doi.org/10.1016/j.apsb.2022.06.007
3. Huitong Ruan, Wenguo Cui*. A Removable Bioorthogonal Catalytic Patch: A Local “Landmine”. Matter 2021, 4(8), 2601-2602.
4. Huitong Ruan, Shengyu Yao, Songli Wang, Ruifeng Wang, Cao Xie, Haiyan Guo, Weiyue Lu*. Stapled RAP12 Peptide Ligand of LRP1 for Micelles-Based Multifunctional Glioma-Targeted Drug Delivery. Chemical Engineering Journal 2021, 403, 126296.
5. Huitong Ruan, Linlin Bu, Quanyin Hu, Hao Cheng, Weiyue Lu*, Zhen Gu*, Strategies of Combination Drug Delivery for Immune Checkpoint Blockades, Advanced Healthcare Materials 2019, 8(4), e1801099.
6. Huitong Ruan#, Zhilan Chai#, Qing Shen, Xishan Chen, Bingxia Su, Cao Xie, Changyou Zhan, Shengyu Yao, Huan Wang, Mingfei Zhang, Man Ying, Weiyue Lu*. A Novel Peptide Ligand RAP12 of LRP1 for Glioma Targeted Drug Delivery. Journal of Controlled Release 2018, 279, 306-315.
7. Huitong Ruan#, Xishan Chen#, Cao Xie, Beibei Li, Man Ying, Yu Liu, Mingfei Zhang, Xuesai Zhang, Changyou Zhan, Wuyuan Lu, Weiyue Lu*. Stapled RGD Peptide Enables Glioma-Targeted Drug Delivery by Overcoming Multiple Barriers. ACS Applied Materials & Interfaces 2017, 9(21) 17745-17756.
8. Dandan Zheng#, Wei Chen#, Huitong Ruan#, Zhengwei Cai, Xiuyuan Chen, Tongtong Chen, Yuhui Zhang, Wenguo Cui*, Hao Chen*, Hongxing Shen*. Metformin-Hydrogel with Glucose Responsiveness for Chronic Inflammatory Suppression. Chemical Engineering Journal 2022, 428, 131064.（Q1, IF=16.744）
9. Qidong Liu#, Huitong Ruan#, Zhihao Sheng#, Xiaoru Sun, Siguang Li*, Wenguo Cui*, Cheng Li*. Nanoantidote for Repression of Acidosis pH Promoting COVID-19 Infection. View 2022, 20220004, 1-16.
10. Dandan Zheng#, Huitong Ruan#, Wei Chen, Yuhui Zhang, Wenguo Cui*, Hao Chen*, Hongxing Shen*. Advances in extracellular vesicle functionalization strategies for tissue regeneration. Bioactive Materials 2022 https://doi.org/10.1016/j.bioactmat.2022.07.022.
11. Quanyin Hu#, Hongjun Li#, Edikan Archibong, Qian Chen, Huitong Ruan, Sarah Ahn, Elena Dukhovlinova, Yang Kang, Di Wen, Gianpietro Dotti*, Zhen Gu*, Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets. Nature Biomedical Engineering 2021, 5, 1038-1047
12. Quanyin Hu, Wujin Sun, Jinqiang Wang, Huitong Ruan, Xudong Zhang, Yanqi Ye, Song Shen, Chao Wang, Weiyue Lu, Ke Cheng, Gianpietro Dotti, Joshua F. Zeidner, Jun Wang, Zhen Gu*. Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy. Nature Biomedical Engineering 2018, 2, 831-840